Polyphyllin VII（68124-04-9）

Biological activity: Parisaponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the root and rhizome of Trillium tschonoskii Maxim. The apoptosis of K562/ADR cells induced by Parissaponin VII is related to the inhibition of Akt/p38MAPK and P-gp. PaChemicalbookrissaponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins (Bax and cytochrome c), and reduces the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1 and p-Akt. Parissaponin VII induces strong autophagy in K562/ADR cells, which can be used for the study of leukemia.

Chemical properties: white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Paris polyphylla.

Usage: Parisian saponin Ⅶ has the functions of anti-inflammation, anti-tumor, anti-virus, cholesterol lowering, blood pressure lowering, etc. Purpose: used for content determination/identification Chemicalbook/pharmacological experiment, etc.

Pharmacological effect: It has the effects of hemostasis, expectorant and bacteriostasis, sedation and analgesia, anti-early pregnancy and sperm killing, and anti-cytotoxicity. It is clinically used to treat functional uterine bleeding, neurodermatitis, surgical inflammation, and tumor, and has significant curative effect.

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