Alantolactone(546-43-0)

Overview: Inulahelenium L. is a perennial herb of the genus Cymbidium in Compositae. It is mainly produced in Hebei. In addition, it is also produced in Zhejiang, Sichuan, Henan, Shanxi, Shaanxi, Gansu and Xinjiang. Its root is used for medicine, which has the effects of invigorating the spleen and stomach, regulating qi and relieving depression, relieving pain and calming the fetus. It is used for chest and flank pain, abdominal distension, vomiting and diarrhea, chest and flank contusion, pain in side gas, and fetal restlessness. Modern pharmacology has proved that the effective component of its volatile oil, alantolactone, has good repellent effect, antibacterial effect, exciting and inhibiting effect on cardiovascular system, and isoalantolactone also has good repellent effect. Chemicalbook has reported on the separation of ciumanolactone and iso-alignolactone from ciumanolactone. The author can separate the two components by taking advantage of the different positions of the double bonds of the two components and the different firmness of the complexes formed with Ag+. Therefore, two single crystal components were separated from the acetone soluble part of civil incense by Ag+complex column chromatography. According to their physicochemical constants and spectral data analysis, they were identified as alantolac-tone (I) and isoalantolactone (II). It was found that the extraction effect of acetone on civil-lactone and iso-alignolactone was better than that of petroleum ether. At the same time, this process was easy to carry out large-scale industrial production [3].

Chemical properties: soluble in ethanol, chloroform, benzene, ether and oil, almost insoluble in water. It comes from the root of Inulahelenium L., a compositae plant, and the leaves of Inulagrandischrenk, a convoluted compound flower.

Use: used for content determination/identification/pharmacological experiment, etc.

Pharmacological effect:

1. Insect repellent: the effect is similar to that of the year of the mountain. It can also repel roundworm and cat parasite.

2. Antibacterial: In vitro experiments have proved that at 0. Chemicalbook1 μ G/ml can inhibit the growth of Mycobacterium tuberculosis. Drug administration can delay the onset of guinea pigs infected with Mycobacterium tuberculosis, but it can not completely stop it. In addition, it has a strong antifungal effect.

3. Others: low concentration of drugs can excite isolated frog heart, while high concentration can inhibit and stop it in diastole. When the blood vessels of frog hind limbs and rabbit ears were perfused, the drugs with low concentration had a slight dilation effect, while the drugs with high concentration had a contraction effect. It also has certain effects on blood pressure and respiration of animals.

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