Luteolin（ 491-70-3）

Pharmacological effects: 1. Anti-tumor: The inhibitory effect of luteolin on the proliferation of tumor cells is mainly through inhibiting the activity of some intracellular kinases and blocking the cell cycle. 2. Antioxidation: The antioxidant effect of luteolin is mainly manifested in its oxidation reaction as a reducing agent, enhancing the activity of biological antioxidant system, etc. 3. Anti-inflammatory: The anti-inflammatory activity of luteolin is mainly manifested in its ability to reduce the activity of inflammatory factor transcription regulator, and reduce the production of pro-inflammatory cytokines and inflammatory mediators. 4. Neuroprotection: Luteolin has a protective effect on the learning and memory ability of the nervous system. 5. Anti-fibrosis: Luteolin can reduce the degree of liver fibrosis, the content of hydroxyproline (HYP), malondialdehyde (MDA) and the expression of type I procollagen mRNA in liver tissue, and inhibit the proliferation and collagen synthesis of hepatic stellate cells (HSC) in vitro. It can also improve the histopathological changes of pulmonary fibrosis caused by bleomycin, reduce the lung weight index, significantly reduce the increase of MDA and HYP, and inhibit the transforming growth factor in lung tissue- β 1（TGF- β 1) The expression of mRNA can inhibit the proliferation of human embryonic lung fibroblasts and promote their apoptosis in vitro. 6. Anti-fertility and hormonal effect: Luteolin has significant dose-dependent anti-implantation activity. After oral administration, it can significantly increase the weight, diameter, thickness of endometrium and height of its epithelial cells. It has estrogen-like effect when used alone, but it shows anti-estrogen effect when used with ethinylestradiol. 7. Others: Luteolin can inhibit a variety of bacteria and viruses, such as Staphylococcus aureus, Escherichia coli, herpes simplex virus, poliovirus, coxsackie B3 virus, etc. It can inhibit the activity of AIDS virus HIV-1 integrase and has potential anti HIV effect. Luteolin can bind to the s2 protein of severe acute respiratory syndrome (SARS) coronavirus, thus inhibiting the virus from entering the host cell. Luteolin also has the effect of anti-Leishmania donovani and inhibits its growth by inhibiting the action of topoisomerase I and topoisomerase II of Leishmania donovani. In addition, luteolin also has the function of immune regulation