Tadalafil（171596-29-5）

Tadalafil (Tadalafil) has a molecular formula of C22H19N3O4 and a molecular weight of 389.4. It has been widely used in the treatment of male erectile dysfunction since 2003, and its trade name is Cialis. In 2008, Eli Lilly sold the commercial expansion right of this product for PAH treatment to the combined treatment company. In June 2009, FDA approved tadanafil for the treatment of patients with pulmonary hypertension (PAH) in the United States under the trade name of Adcirca. Tadanafil was introduced as a drug for the treatment of ED in 2003. It takes effect 30 minutes after administration, but its best effect is 2 hours after the onset, and the effect can last for 36 hours, and its effect is not affected by food. The dose of tadanafil is 10 or 20 mg, and the recommended initial dose is 10 mg. The dose adjustment is based on the patient's reactions and adverse reactions. Early market research showed that after 12 weeks of oral administration of 10 or 20 mg of tadanafil, the effective rates were 67% and 81% respectively. Many studies have shown that tadanafil has good efficacy in the treatment of ED.