NMN( β- Nicotinamide mononucleotide)(1094-61-7)

character: β- The appearance of nicotinamide mononucleotides is white to yellowish, which is crystalline powder without obvious odor.

Introduction Nicotinamide mononucleotide is also called β- Nicotinamide mononucleotide (NMN) is the synthetic substrate of coenzyme I, and NMN is also used in anti-aging research. Research shows, β- NMN can also regulate the secretion of insulin and affect the level of mRNA expression, β- NMN has a broad application prospect in the field of medical treatment Chemicalbook. β- Nicotinamide mononucleotide is the product of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) reaction and the key NAD+intermediate. It improves glucose tolerance by restoring the NAD+level of T2D mice induced by HFD. It also enhances the insulin sensitivity of the liver and partially restores the gene expression related to oxidative stress, inflammatory reaction and circadian rhythm through SIRT1 activation

Purpose: In mammals, β- Nicotinamide mononucleotides are generated by nicotinamide (Nam) under the catalysis of Nampt (a protease in vivo), and then nicotinamide mononucleotides are generated by nicotinamide mononucleotides adenosine transferase to NAD+. Nicotinamide mononucleotide is a direct way to supplement NAD+. Nicotinamide mononucleotides can reverse aging by significantly improving the repair ability of DNA damage in cells. Nicotinamide mononucleotides will be converted into "nicotinamide adenine dinucleotide (NAD)" substances essential for energy metabolism in the body. In mouse experiments, it was confirmed that nicotinamide mononucleotide can activate a gene called acetylase in the body, so as to play a role in prolonging life and treating diabetes. NAD is a substance that can be produced by the human body. Research has confirmed that the content of NAD in the body will decrease with the increase of age.

Application: β- Nicotinamide mononucleotide is the precursor of NAD+, the cofactor of human longevity protein. NAD+is an important coenzyme in the tricarboxylic acid cycle, promoting the metabolism of sugar, fat and amino acid, and participating in the synthesis of energy; NAD+is the only substrate of coenzyme I consuming enzyme (the only substrate of DNA repair enzyme PARP, the only substrate of long-lived protein Sirtuins, and the only substrate of cyclic ADP ribose synthetase CD38/157). NAD+participates in all aspects of human metabolism, and is the key coenzyme. Without NAD+, metabolism will not work. The elderly will lack NAD+, so all kinds of big and small problems will come. By adding NAD+, they can comprehensively fight aging. Pre clinical studies have shown that NMN has a variety of pharmacological activities in heart and brain ischemia, Alzheimer's disease, type 2 diabetes and obesity caused by diet and age. As a precursor of NAD+, NMN mainly synthesizes NAD+in vivo to play a pharmacological role, all of which are related to the lack of NAD+.

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