Podophyllotoxin(518-28-5)

Introduction Podophyllotoxin, also known as podaferol, is a non-alkaloid lignan toxin. It is extracted from the root of podophylla. Its alcohol solution and ointment, with the trade names of Kangdinglai and Huaverruca enemy respectively, can be used as external drugs to treat Chemicalbook condyloma acuminatum caused by human papillomavirus. Podophyllotoxin and its synthetic derivatives, such as etoposide and teniposide, have shown wide choice in medical applications such as antiviral and anti-tumor agents. Its anticancer activity has been studied to a large extent and used in the chemotherapy of lung cancer, lymphoma and reproductive tumors.

Chemical properties: white acicular crystal, easily soluble in methanol and chloroform, derived from the root and stem of the berberidaceae plant and the podophyllon plant in the Berberidaceae family - the root and stem of the Chinese podophyllon.

Purpose: A microtubule assembly and DNA topoisomerase II inhibitor. Podophyllotoxinisapotentinhibitorofmicrotubuleassemblythatbindsatthecolchicinesiteoftubulin.Itisanantineoplasticglucosideandantitumoragent.Also,podophyllotoxinisaTopoII(DNAtopoisomeraseII)andtubulininhibitor.

Uses: mainly used for condyloma acuminatum, but also for other viral warts to inhibit the assembly of microtubules; Antitumor. Clinically, it is used for acute monocytic and acute myelomonocytic leukemia, acute myelocytic leukemia, chronic eosinophilic leukemia, small cell lung cancer, non-Hodgkin's lymphoma, testicular cancer, etc.

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