Overview Ursolic acid, also known as ursolic acid and ursolic acid, is a pentacyclic triterpenoid compound extracted from the evergreen vine shrub Ursolic acid of Rhododendron family. It has a special smell. It can obtain large and shiny prisms in anhydrous ethanol, and fine hair-like needle crystals in dilute ethanol. mp285℃~288℃,[ α] D20+66 ° (pyridine), easily soluble in dioxane, pyridine, soluble in methanol, ethanol, butanol, butanone, slightly soluble in acetone, slightly soluble in benzene, chloroform, ether, insoluble in water and petroleum ether. It has many biological effects, such as sedation, anti-inflammatory, antibacterial, anti diabetes, anti ulcer, lowering blood sugar, etc. In recent years, it has been found that Chemicalbook has anti-carcinogenic, anti-cancer-promoting, induction of F9 teratoma cell differentiation and anti-angiogenesis effects, which is very likely to become a low-toxicity and high-efficiency new anti-cancer drug. In addition, ursolic acid has obvious antioxidant function and is a strong antioxidant. Its antioxidant effect has a positive effect on anti-aging, skin freckle removal and pigment removal of the human body, so it is widely used as a raw material for medicine and natural whitening cosmetics. Some experiments show that ursolic acid can inhibit the activity of 5-lipoxygenase and cyclooxygenase in the metabolism of arachidonic acid, and prevent the formation of prostaglandins and leukotrienes, This may be the reason why ursolic acid inhibits inflammation and lipid peroxide.
Efficacy and role: Ursolic acid is a triterpenoid compound existing in natural plants, which has many biological effects such as sedation, anti-inflammatory, antibacterial, anti diabetes, anti ulcer, blood sugar reduction, etc. Ursolic acid also has obvious antioxidant function. In addition, Ursolic acid can also inhibit cell proliferation and metastasis by inducing apoptosis, inhibiting cell cycle progress, And to show its anticancer activity by reducing tumorigenesis through multiple signal pathways. At present, experimental research has shown that ursolic acid inhibits a variety of cancers, including bladder cancer cancer, colon cancer, breast cancer, cervical cancer, gastric cancer, glioma, neuroblastoma, fibrosarcoma, liver cancer, leukemia, multiple myeloma, lung cancer, ovarian cancer, pancreatic cancer, thyroid adenocarcinoma, melanoma and prostate cancer. In order to further understand and study the effect of ursolic acid on cancer and open a new chapter in chemotherapy, scientists have carried out a variety of in vivo and in vitro studies.
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