honokiol( 35354-74-6)

Magnolia officinalis extract: Magnolia officinalis, also known as Xiangpu, Chipu, Ziyou Magnolia officinalis, is a commonly used Chinese medicine. It was first published in Shennong's Classic of Materia Medica and was listed as a Chinese product. Magnolia officinalis extract is a product extracted from the dried root bark, stem bark or branch bark of Magnolia officinalis, etc., and the commercial extract usually standardizes the content of magnolol and honokiol. [Distribution] There are about 90 species of Magnolia plants in the world, about 30 species in China, of which about 20 species have medicinal value. Magnolia officinalis is born at the sunny hillside and forest edge with fertile and deep soil at an altitude of 300~1700m. [Origin] Magnolia officinalis is mainly distributed in western Hubei, southern Sichuan, southern Shaanxi and southern Gansu; Magnolia officinalis is mainly distributed in Jiangxi, Anhui, Zhejiang, Fujian, Hunan, Guangxi and northern Guangdong. Magnolia officinalis and Magnolia officinalis are mostly cross-distributed and cultivated in large areas. [Main ingredients] Magnolia bark contains honokiol, honokiol, isohonokiol and other components. Trihydroxy honokiol, deoxy-trihydroxy honokiol, trihydroxy honokiol, polyhonokiol A and C were isolated from the ethyl acetate extract of magnolia officinalis. The bark contains about 1% volatile oil, which mainly contains β- Oleanol; Still included α- Pinene β- Pinene, limonene, bornyl acetate. The bark also contains magnolia curculine. The leaves also contain honokiol and honokiol. [Harvesting and processing] From April to June, peel the dried bark of trees that have been growing for more than 15 years, boil it in boiling water, pile it in the pit, cover it with green grass to make it "sweat", and steam it soft when the water seeps from the inside and the inner surface becomes purplish brown or brown, take it out, roll it into a tube, dry it in the sun or dry it on the kang. Root bark and branch bark can be directly dried in the shade after being peeled off.

Pharmacological effects: 1. The effect of anti-pathogenic microorganisms: Houpu decoction has inhibitory effects on gram-positive bacteria such as staphylococcus, hemolytic streptococcus, pneumococcus, pertussis, and gram-negative bacteria such as anthrax, dysentery, typhoid, paratyphoid, vibrio cholerae, Escherichia coli, proteus, bacillus subtilis, and diphtheria, among which staphylococcus has the strongest inhibitory effect. At the concentration of 15%, it can inhibit the skin fungi of experimental animals, such as Tinophyton vulgaris, Trichophyton concentricus, Trichophyton rubrum, Trichophyton prettivum and so on. Magnolia officinalis decoction has some effects on improving the substantive pathological damage of experimental viral hepatitis in mice. Magnolol has significant antibacterial activity against gram-positive bacteria and acid-resistant bacteria; The anti-caries effect of magnolol is very significant, and the minimum inhibitory concentration is 6.3 μ G/ml, its antibacterial activity is stronger than the typical antibacterial alkaloid berberine (MIC: 50 μ g/ml)。 The saturated aqueous solution of Magnolia officinalis and volatile oil of Magnolia officinalis has certain antibacterial effect on Staphylococcus aureus, Sarcina and Bacillus subtilis. 2. Effect on cardiovascular system: honokiol and honokiol inhibit the formation of thromboxane B2 under various conditions, and the increase of intracellular Ca2+caused by arachidonic acid or collagen is also inhibited by both. Honokiol can inhibit the activity of cyclic nucleotide phosphodiesterase stimulated by CaM, and honokiol can combine with CaM in the presence of Ca2+, thus antagonizing its activation of phosphodiesterase. In addition, honokiol can stimulate the basic activity of CaM-dependent phosphodiesterase. 3. Anti-tumor effect Magnolol and its hydroxymethyl derivatives have obvious inhibitory effect on secondary skin tumor in mice. The three extracted components of Magnolia officinalis, including lignans, honokiol, honokiol and monoterpene magnolol, are antagonists of the activation of Epstein-Barr virus early antigen (EBv-EA) induced by 12-O-tetradecyl phorbol-13-acetate (TPA). The methanol extract of magnolia officinalis and magnolol have obvious inhibitory effect on the skin tumor of mice caused by the second stage carcinogenesis experiment in vivo.

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