Berberine hydrochloride（633-65-8)

Berberine hydrochloride, also known as berberine hydrochloride, has long been used in clinic as a heat-clearing, detoxicating and antibacterial drug. It is often used to treat bacillary dysentery, acute gastroenteritis, chronic cholecystitis, ophthalmic conjunctivitis, suppurative otitis media and other diseases, and has significant curative effect. Berberine hydrochloride is an isoquine chemicalbookline alkaloid, which exists in many plants of 4 families and 10 genera, including Berberidaceae. Berberine can precipitate yellow needle-like crystals from ether. Berberine is a quaternary ammonium alkaloid, and its salts have relatively low solubility in water, such as 1 ∶ 500 for hydrochloride and 1 ∶ 30 for sulfate.

Mechanism of action: Berberine hydrochloride has inhibitory effect on dysentery bacilli, Escherichia coli, pneumococcus, staphylococcus aureus, streptococcus, typhoid bacillus and amoeba. It is mainly used for intestinal infection and bacillary dysentery. It is also found that this product has anti-arrhythmia effect. Berberine has strong anti-tumor activity in vitro and in vivo and can induce B16 cell differentiation; It has synergistic effect with cytarabine hydrochloride in vitro.

Antibacterial effect: Berberine has antibacterial effect on hemolytic streptococcus, Staphylococcus aureus, Neisseria gonorrhoeae, Shigella flexneri and Shigella dysenteriae, and has enhanced phagocytosis of white blood cells. Berberine hydrochloride (commonly known as berberine hydrochloride) has been widely used in the treatment of gastroenteritis, bacillary dysentery, etc., and also has certain effects on tuberculosis, scarlet fever, acute tonsillitis and respiratory tract infection.

Pharmacological effect: It has a broad antibacterial spectrum and has antibacterial effect on a variety of gram-positive and negative bacteria in vitro, including hemolytic streptococcus, staphylococcus aureus and vibrio cholerae. Meningococci, Shigella dysenteriae, typhoid bacillus, diphtheria bacillus, etc. have strong inhibitory effects. They are bacteriostatic at low concentrations and bactericidal at high concentrations. It can also inhibit influenza virus, amoeba, leptospira and some skin fungi. In vitro experiments confirmed that berberine can enhance the phagocytosis of white blood cells and hepatic reticuloendothelial system. Shigella, hemolytic streptococcus, staphylococcus aureus, etc. are easily resistant to this product. This product has no cross-resistance with penicillin, streptomycin, etc.

Property: light yellow crystalline powder; It has a slight odor and a bitter taste. Use: It is effective in treating enteritis, bacterial dysentery and other intestinal infections, conjunctivitis, suppurative otitis media, etc. Recently, it was also found that the product was blocked α- Receptor, antiarrhythmic effect.

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