【Company News】Congratulations to our technical team on the successful delivery of the following synthetic technology projects to our foreign customers

Product 1：

【1】 Product background

【2】Technical data

✓ Chiral synthesis purity up to 97% (HPLC-MS verification)
✓ Continuous flow process reduces energy consumption by 60% (compared to traditional kettle reaction)
✓ Exclusive enzyme catalyzed system to avoid heavy metal residues

【3】Technological advantage
✓ Different substituents can be modularized
✓ Suitable for gram to kilogram magnification

【4】Commercial application
Pharmaceutical development: As a key fragment of JAK/EGFR kinase inhibitors
Materials Science: Precursors of electronic transport layer materials for organic light-emitting diodes (OLEDs)

Product2：

【1】 Product background

【2】Technical data

✓ Plant source: Mainly found in: Citrus paradisi peel (content 0.12%), Citrus aurantium leaves
✓ Enzymatic glycosylation (β-glucosidase catalyzed, conversion rate > 85%)
✓ Purity can reach more than 98%

【3】Technological advantage

✓ Green technology
✓ Production from mg grade to kg grade

【4】Commercial application

1. Functional food development
Approved in Japan as a "Functional ingredient for regulating blood sugar" (50-100mg daily intake);A brand of meal replacement powder added 0.5% to enhance antioxidant capacity
2. Cosmetic efficacy raw materials
Whitening mechanism: Inhibition of tyrosinase (IC₅₀=32 μM) and no cytotoxicity;Anti-photoaging: Reduced UVB-induced MMP-1 expression (20% more effective than phloretin)
3. Pharmaceutical intermediates：Precursors of semi-synthetic flavonoids

Product3:

【1】 Product background

【2】Technical data

✓ Purity can reach more than 98%

【3】Technological advantage

✓Synthesis route: Key steps: condensation of L-aspartate with (S)-2, 4-diaminobutyric acid (EDC/HOBt activation); Formamidine reaction (using S-methyl isothiourea sulfate); Ammonia water to adjust the pH into ammonium salt
✓Purification process: ion exchange chromatography (DEAE cellulose column, 0-0.5M NaCl gradient elution)

【4】Commercial application

a. Functional mechanism:
Arginase inhibition: Competitive inhibition Ki= 0.8μM (potential for cardiovascular disease treatment)
Regulation of NO synthesis: by affecting the L-arginine metabolic pathway
b. In the field of medicine
Pulmonary hypertension treatment: Preclinical studies have shown a 30% reduction in right ventricular hypertrophy in rat models
Immunomodulator: promotes macrophage M2 polarization (IL-10 secretion ↑2 times)

Product4:

【1】 Product background

【2】Technical data

✓ Purity can reach more than 99%

【3】Technological advantage

A. Plant distribution
It mainly exists in the root of Codonopsis pilosula, the content is 0.02-0.05%;High content variety: C. tangshen can reach 0.08%
B. Extraction and purification process
Green extraction: supercritical CO₂ extraction (40℃, 25MPa) yield increased by 30%;Chromatographic technology:Silica gel column gradient elution (petroleum ether: ethyl acetate 10:1→1:1);High speed countercurrent chromatography (HSCCC) separation purity > 99%

【4】Commercial application

1. Functional food development
Approved by the Chinese Health Commission as a new food raw material (added in 2023);Dosage of a brand of anti-fatigue beverage: 50mg/100mL
2. Drug excipients
As a quality marker for traditional Chinese medicine injections (such as Shenmai Injection) (added in the 2025 edition of Pharmacopoeia)
3. Cosmetic efficacy
Inhibition of melanin synthesis by 0.1% addition (20% better than arbutin);Combined with hyaluronic acid to enhance skin barrier function (transdermal water loss ↓22%)