6-Methyleneandrost-4-ene-3,7-dione(19457-55-7)

Overview: The Chinese name of the intermediate of exemestane is 1,4-diene-3,17-dione-6-methyleneandrostane. exemestane is an irreversible steroid aromatase inactivator, which is similar in structure to the natural substrate of the enzyme androstenedione. It is a pseudo-substrate of aromatase, which can be inactivated by irreversible binding with the active site of the enzyme (also known as "self-destructive inhibition"), thus significantly reducing the estrogen level in the blood circulation of postmenopausal women, However, it has no significant effect on the biosynthesis of corticosteroids and aldosterols in the adrenal gland. When it is 600 times higher than the concentration of aromatase inhibition, it has no significant effect on other enzymes in the steroid production pathway. It can inhibit estrogen production by inhibiting aromatase, which is an effective and selective treatment for postmenopausal hormone dependent breast cancer.