Estriol(50-27-1)

Natural hormone: Estriol is a natural hormone, which is the metabolite of estradiol in the body and mainly exists in urine. Estrogen activity is small, oral activity is about 6 times that of estrone, but it is weaker than estradiol, and has no carcinogenic effect. The level of estradiol in the body does not change after taking the drug. Estriol has a selective effect on the vagina and cervical canal, but has no effect on the uterine body and endometrium. Animal experiments show that estriol has a stronger effect on vaginal epithelial keratinization than estradiol, and can promote vaginal epithelial proliferation, surface cell keratinization, mucosal angiogenesis and vaginal epithelial wound healing, but has a weaker effect on mouse uterine weight gain; At the same time, estriol can enhance the function of cervical cells, make cervical muscle fibers proliferate, and increase the elasticity and softness of the cervix. In addition, estriol has a feedback inhibition effect on the hypothalamus and pituitary, but does not inhibit ovulation, and only has a significant effect on the corpus luteum. Therefore, it can be used as an auxiliary drug for mid-term induction of labor and artificial abortion and the treatment of various menstrual diseases. Estriol also has an obvious effect on the hematopoietic system, can reduce the permeability and fragility of blood vessels, and can be used for the treatment of various bleeding. It also has the effect of rapidly increasing peripheral white blood cells. It generally takes effect 1 to 3 days after the treatment, but the action time is short, and it is effective for leukopenia caused by radiotherapy and chemotherapy.