Genistein（446-72-0）

Pharmacological action: genistein, also known as genistein, is a polyphenol compound that can be found in plants such as soybean and red clover, and its molecular structure is similar to 17 β- Estradiol, with antioxidant activity and high affinity for estrogen receptor, can inhibit the activity of tyrosine protein kinase (PTK) and topoisomerase II, and can induce programmed cell death, improve anticancer efficacy, and inhibit angiogenesis. It is a type of flavonoids (also called isoflavones). They are often found together with isoflavones called daidzein, which are called soybean isoflavones. The benefits of these compounds on human health have been widely studied. They are a potential chemopreventive agent for cancer and have a significant impact on the prevention of cancer and other diseases. Genistein is the main phytoestrogen studied at present. Plant source: leguminous plant dyewood (broom). Clinical application: It can be used for women's beauty care and prevention of blood diseases and cancer. Genistein has the structure of polyphenol hydroxyl, and the hydrogen atom on the phenol hydroxyl is easy to separate from the oxygen atom under the external action to form hydrogen ion and exert the reduction effect, which is the structural basis of genistein's antioxidant and reductive properties. Therefore, such substances in food can resist superoxide anion free radicals, block the chain reaction of free radicals, and play an antioxidant role. Genistein is not a hormone, but it is called phytoestrogen because it can combine with estrogen receptor to play a weak estrogen effect. Because the activity of isoflavone is 1/1000 of that of estradiol, it competitively binds estrogen receptor with estradiol, showing a two-way regulatory effect. The estrogen effect produced is much lower than the harmful effect of estradiol, and thus has a protective effect on hormone-related diseases, such as menopausal syndrome, osteoporosis, elevated blood lipids, etc; For those with high estrogen level, it has anti estrogen activity, can prevent and treat breast cancer and endometritis, and has two-way regulation and balance function. Genistein can reduce serum cholesterol and triglyceride in rats with hyperlipemia caused by trinitrotoluene WR1339, especially for the latter.