NMN( β- Nicotinamide mononucleotide)(1094-61-7)

Purpose: In mammals, β- Nicotinamide mononucleotides are generated by nicotinamide (Nam) under the catalysis of Nampt (a protease in vivo), and then nicotinamide mononucleotides are generated by nicotinamide mononucleotides adenosine transferase to NAD+. Nicotinamide mononucleotide is a direct way to supplement NAD+. Nicotinamide mononucleotides can reverse aging by significantly improving the repair ability of DNA damage in cells. Nicotinamide mononucleotides will be converted into "nicotinamide adenine dinucleotide (NAD)" substances essential for energy metabolism in the body. In mouse experiments, it was confirmed that nicotinamide mononucleotide can activate a gene called acetylase in the body, so as to play a role in prolonging life and treating diabetes. NAD is a substance that can be produced by the human body. Research has confirmed that the content of NAD in the body will decrease with the increase of age.

Application: β- Nicotinamide mononucleotide is the precursor of NAD+, the cofactor of human longevity protein. NAD+is an important coenzyme in the tricarboxylic acid cycle, promoting the metabolism of sugar, fat and amino acid, and participating in the synthesis of energy; NAD+is the only substrate of coenzyme I consuming enzyme (the only substrate of DNA repair enzyme PARP, the only substrate of long-lived protein Sirtuins, and the only substrate of cyclic ADP ribose synthetase CD38/157). NAD+participates in all aspects of human metabolism, and is the key coenzyme. Without NAD+, metabolism will not work. The elderly will lack NAD+, so all kinds of big and small problems will come. By adding NAD+, they can comprehensively fight aging. Pre clinical studies have shown that NMN has a variety of pharmacological activities in heart and brain ischemia, Alzheimer's disease, type 2 diabetes and obesity caused by diet and age. As a precursor of NAD+, NMN mainly synthesizes NAD+in vivo to play a pharmacological role, all of which are related to the lack of NAD+.