Arecoline hydrobromide(300-08-3)

Physical and chemical properties of chemical control sample of traditional Chinese medicine: this product is white or light yellow crystalline powder; It is odorless and bitter. It is easily soluble in water and ethanol, slightly soluble in chloroform and ether, and the nature of the aqueous solution is relatively stable, so it should be stored in a light-proof container.

Study on antithrombotic effect: to study the antithrombotic and thrombolytic effects of arecoline hydrobromide on thrombus in vivo and in vitro. Methods: The thrombolytic effect of arecoline hydrobromide was investigated by dissolving human blood clot and human platelet plasma clot in vitro; The antithrombotic effect of arecoline hydrobromide in vivo was investigated by using the model of carrageenan-induced tail vein thrombosis in mice. Results: Arecoline hydrobromide can accelerate the dissolution of human blood clots and platelet plasma clots in vitro in a dose-dependent manner; It has the effect of anti-carrageenan-induced tail vein thrombosis in mice. Conclusion: Arecoline hydrobromide has antithrombotic effect in vivo and in vitro.

Pharmacological effect: Arecoline hydrobromide has a strong paralyzing effect on the tapeworm muscle, making the worm lose its ability to attach to the intestinal wall. In addition, the muscarinic effect of the drug on the host strengthens the intestinal peristalsis, increases the secretion of digestive glands, and is conducive to the rapid elimination of paralyzed worms. This product is effective for all tapeworms in dogs. It can also expel Taenia solium, Taenia multicephalus and Echinococcus granulosus. It can also expel tapeworm in poultry.