Fangchinoline(436-77-1)

Overview: fangchinoline, also known as tetrandrine and magnolia, is the dried root of tetrandrine, which has many biological functions such as anti-inflammatory and analgesic, anti-oxidation, non-specific blocking of calcium ion channels, inhibiting histamine release, expanding coronary artery, reducing myocardial oxygen consumption, inhibiting platelet aggregation, lowering blood pressure, lowering blood sugar, and so on. In some cells, tetrandrine can achieve anti-tumor effect by blocking cell cycle and inducing autophagy and apoptosis. Tetrandrine can significantly inhibit the proliferation and metastasis of A375 cells, and can be used as a potential chemotherapy drug for melanoma.

Pharmacological action: fangchinoline (FAN) is often used as an analgesic, anti-rheumatic and anti-hypertensive drug in traditional Chinese medicine. In recent years, its anticancer effect has attracted people's attention. The literature indicates that it can inhibit tumor cells by inducing cell apoptosis, blocking cell cycle progression and inhibiting tumor cell invasion. In addition, tetrandrine, as one of the main alkaloids contained in tetrandraceae plants, has obvious analgesic, antipyretic, anti-inflammatory, diuretic, coronary artery dilation, blood pressure reduction, anticancer and other effects, while its large dose or long-term use will have certain toxicity to liver and kidney, especially liver damage, and the degree of damage is proportional to the drug dose. In addition, tetrandrine may become a potential drug for the treatment of prostate cancer. The expression of proapoptotic protein Bax and activated Caspase-3 protein also increased significantly, while the expression of apoptosis-inhibiting protein Bcl-2 decreased correspondingly

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