Levodopa（59-92-7）

Introduction: Levodopa is the precursor of dopamine, and is the internationally used drug name. Different manufacturers have different trade names when drugs are marketed. Oral levodopa tablets generally disintegrate and dissolve in the stomach, then discharge to the duodenum, then reach the small intestine, and absorb blood at the upper end of the small intestine. A small part of levodopa can finally enter the brain through the "blood brain barrier", and be ingested by substantia nigra nerve cells or other nerve cells. Under the action of dopamine decarboxylase, a carboxyl group is removed and converted into dopamine, thus supplementing dopamine in the brain, Reduce the symptoms of Parkinson's disease.

Chemical property: white or almost white crystalline powder. Melting point 285.5 ℃ (decomposition). Easily soluble in dilute acid, slightly soluble in water, insoluble in ethanol, ether and chloroform. It is odorless and tasteless, and turns black in the air.

Purpose Levodopa is one of the effective drugs for the treatment of tremor paralysis at present. It is one of the precursors for the synthesis of norepinephrine and dopamine in the body of Chemicalbook, belonging to catecholamine. Levodopa can enter the brain through the blood-brain barrier, and play a role by decarboxylation of Doma decarboxylase into dopamine. However, the obvious effect is slow and the side effects are large. Rat oral LD50>4000mg/kg.

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