Shaanxi Cuikang Pharmaceutical Technology Ginsenoside rg3 Promotion

陕西萃康医药科技人参皂苷rg3推介

名称（name）： 人参皂苷rg3（Ginsenoside Rg3）

CAS：38243-03-7

分子式（Molecular formula）：C42H72O13

分子量（molecular weight）：785.01

结构式（Structural formula）：

人参是五加科人参属植物，是中国传统名贵中药，被称为“百药之王。人参的主要成分包括人参皂苷、人参多糖、挥发油以及多种微量元素等，其中人参皂苷是其标志性成分，具有增强免疫力、抗衰抗疲劳、抗肿瘤增殖以及保护神经元等功效。1980年，日本学者北川勋最先从人参中提纯了人参苷Rg3，并鉴定了其分子结构。现代研究进展表示，人参皂苷Rg3具有抗肿瘤增殖、抗炎、抗氧化损伤以及降血糖等药理活性；同时也有研究证明其具有抗氧化、抑制黑色素瘤细胞增殖以及炎症反应等化妆品潜在价值。

Ginseng is a plant belonging to the genus Ginseng of the Acanthopanax family, which is a traditional and precious Chinese medicine, go by the name of "The King of Hundred Medicines. The main ingredients of ginseng include ginsenoside, ginseng polysaccharide, volatile oil, and various trace elements, among which ginsenoside is its landmark ingredient, which has the effects of enhancing immunity, anti aging, anti fatigue, anti-tumor proliferation, and protecting neurons. In 1980, Japanese scholar Hiroshi Kitagawa first purified ginsenoside Rg3 from ginseng and identified its molecular structure. Modern research progress indicates that ginsenoside Rg3 has Pharmacological activities such as anti-tumor proliferation, anti-inflammatory, antioxidant damage, and hypoglycemic; At the same time, some studies have demonstrated that it has the potential value of cosmetics such as antioxidant, inhibiting the proliferation of melanoma cells, and inflammatory reactions.

通过筛选合适的酸催化剂以及酸含量、水解温度和水解时间，制备了一种富含高浓度人参皂苷Rg3的人参提取物。采用细胞功效模型探究富含高浓度人参皂苷Rg3的人参提取物体外功效作用的同时，结合人体功效评价试验来进一步验证其化妆品领域应用的功效表现。结果表明：优选DL-酒石酸作为酸催化剂，当酸含量为5%，水解温度为80 摄氏度，水解时间为2 h时，人参皂苷Rg3的转化效率最高，达到64.91 mg/g。高浓度人参皂苷Rg3的人参提取物的细胞模型评价试验显示出其具有修护H2O2氧化应激损伤和抑制TNF-α分泌的作用。同时，结合人体功效评价试验结果来看，高浓度人参皂苷Rg3的人参提取物具有较好的修护皮肤屏障、改善皮肤泛红的功效。

A ginseng extract rich in high concentration ginsenoside Rg3 was prepared by selecting suitable acid catalysts, acid content, hydrolysis temperature, and hydrolysis time. Using a cell efficacy model to explore the in vitro efficacy of ginseng extracts rich in high concentrations of ginsenoside Rg3, combined with human efficacy evaluation tests to further verify their efficacy performance in the cosmetics field. The results showed that DL tartaric acid was selected as the acid catalyst. When the acid content was 5%, the hydrolysis temperature was 80 ℃, and the hydrolysis time was 2 hours, the conversion efficiency of ginsenoside Rg3 was the highest, reaching 64.91 mg/g. Cell model evaluation tests of ginseng extract with high concentration of ginsenoside Rg3 showed that it has the ability to repair H2O2 oxidative stress damage and inhibit TNF- α The role of secretion. At the same time, according to the results of the human efficacy evaluation test, the ginseng extract with high concentration of ginsenoside Rg3 has a good effect on repairing the skin barrier and improving skin redness.

2型糖尿病(T2DM)是临床上常见的慢性疾病，胰岛素抵抗(IＲ)是其发病的早期特征，而肥胖是其诱因之一。因此，通过改善肥胖及其诱导的胰岛素抵抗对治疗T2DM有一定意义。人参皂苷Ｒg3为人参主要有效成分，可通过调节脂质代谢、降低炎症反应、调节肠道菌群等途径治疗T2DM，且新剂型的应用可能会使药物发挥更好的疗效。通过阐明肥胖与IＲ之间的关系，并对不同剂型的人参苷Ｒg3改善T2DM的相关研究进行综述，期为T2DM的治疗提供新思路和新方法，并为人参皂苷Ｒg3的应用提供新途径。

Type 2 diabetes (T2DM) is a common chronic disease in clinic. Insulin resistance (IR) is the early feature of its onset, and obesity is one of its inducements. Therefore, improving obesity and its induced insulin resistance has certain significance in the treatment of T2DM. Ginsenoside Rg3 is the main effective ingredient of ginseng, which can be used to treat T2DM by regulating lipid metabolism, reducing inflammatory reactions, regulating intestinal flora, and other ways. The application of new dosage forms may make the drug play a better therapeutic effect. By clarifying the relationship between obesity and IR, and reviewing the relevant research on improving T2DM with different dosage forms of ginsenoside Rg3, we hope to provide new ideas and methods for the treatment of T2DM, and provide new ways for the application of ginsenoside Rg3.

陕西康医药科技深耕人参皂苷系列近4年，目前已经开发出一系列适合食品保健，化妆品应用的高质量原料。萃康利用绿色生物制造研发的人参皂苷系列，具有成本低，绿色，健康，环保等特点。并且针对于食品保健品的特殊要求可定制不同规格的单体以及进行不同比例的复配；同时研发了针对于化妆品原料特殊要求的可适应不同环境，澄清透亮等特点。

Shaanxi Kang Pharmaceutical Technology has been deeply engaged in the ginsenoside series for nearly 4 years, and has developed a series of high-quality raw materials suitable for food health care and cosmetics applications. The ginsenoside series developed by Cuikang using green biological manufacturing has the characteristics of low cost, green, healthy, and environmental protection. According to the special requirements for food and health products, different specifications of monomers can be customized and different proportions can be compounded; At the same time, it has developed features that can adapt to different environments and are clear and transparent according to the special requirements of cosmetics raw materials.