Bilobalide（33570-04-6）

Bilobalide is the only sesquiterpene substance extracted from the Ginkgo biloba plant. Bilobalide has a good curative effect on cardiovascular and cerebrovascular diseases such as angina pectoris, myocardial infarction, coronary heart disease, hypertension and arrhythmia. Effects on lowering blood pressure and slowing heart rate: Bilobalide has the effect of lowering blood pressure. Its antihypertensive effect is to increase the activity of superoxide dismutase (SOD) in serum, reduce the concentration of malondialdehyde (MDA) in serum, relax blood vessels, reduce diastolic blood pressure and slow down heart rate; and inhibit myocardial cell contraction, reduce systolic force. Secondly, systolic blood pressure can reflect the ejection ability of the heart to a certain extent. By comparing dimethyl sulfoxide and bilobalide, both can reduce systolic blood pressure, but bilobalide is more significant in reducing systolic blood pressure. It shows that bilobalide can dilate peripheral arterioles, reduce peripheral resistance, and lower diastolic blood pressure. The relaxing effect of certain concentrations of Ginkgo biloba extract and bilobalide on rat arterial rings decreases with age of the rats. Protection of myocardial ischemia-reperfusion injury: bilobalide has a significant protective effect on myocardial cells, and the protective effect of bilobalide on myocardial cells and endothelial cells is concentration-dependent, of which 5ng/mL-1 bilobalide is significantly Reduced the death rate of cardiomyocytes and endothelial cells Chemicalbook. Effects on cardiac hemodynamics and coronary flow: Bilobalide can change cardiac hemodynamics, such as by giving normal anesthetized rats intravenous injection of Ginkgo biloba extract to change the hemodynamics of rats, and antagonize Cardiovascular function changes caused by PAF can inhibit myocardial force, slow heart rate, reduce myocardial oxygen consumption, relax blood vessels and visceral smooth muscle, increase coronary flow, and lower blood pressure. Effects on platelets: Ginkgo biloba extract can antagonize platelet activating factors, inhibit platelet aggregation and thrombus formation, improve blood rheology, expand cerebral blood vessels, increase cerebral blood flow, resist free radicals, inhibit glutamate toxicity, and improve cerebral ischemia Energy metabolism disorder and acidosis caused by hypoxia, reduce ischemic cerebral edema, lower blood fat, and resist atherosclerosis. In the treatment of ischemic cerebrovascular disease, Ginkgo biloba preparations improve cerebral blood supply, protect brain cells, promote the recovery of nerve function and improve clinical symptoms through the above effects. Protective effect on the nervous system: bilobalide has a protective effect on central nervous system damage. Bilobalide can shorten the learning reaction time of model mice, prolong the memory time, and reduce the number of mistakes; increase the activity of SOD in mouse brain tissue, reduce the content of MDA, and reduce the activity of cholinesterase and NO content.