Demethyl-Coclaurine（5843-65-2）

Overview: Normethylaconitine, also known as normethylhengzhou aconitine, is an antiarrhythmic drug. This product is the effective ingredient of aconite, which can enhance the myocardial contractility and speed up the heart rate; Dilate heart, brain and peripheral blood vessels; It can improve chronic arrhythmia. It is clinically used for the treatment of chronic arrhythmia and sick sinus syndrome.

Bioactive Demethyl-Cocraurine (HigeChemicalbookamine, Norcoclaurine) is a key component of the root of aconite, a Chinese herbal medicine, and is a beta-2 adrenergic receptor（ β 2-AR). Demethil-Coclaurine can stimulate the phosphorylation of AKT, which requires the activation of PI3K to make cardiomyocytes produce anti-apoptosis effect.