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Biological activity: Guvacinehydrochloride is an alkaloid obtained from betel nut, an inhibitor of GABA transporter, and has moderate selectivity for several cloned GABA transporters, with IC50 values of 14 respectively μ M(hChemicalbookumanGAT-1)，39 μ M(ratGAT-1)，58 μ M(ratGAT-2)，119 μ M(humanGAT-3)，378 μ M (ratGAT-3) and 1870 μ M(humanBGT-3)。
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