L-Valine(72-18-4)

Amino acid: L-valine is one of the branched-chain amino acids (BCAA), which cannot be synthesized by animals themselves. It must be taken from the diet to meet their nutritional needs, so it is a necessary amino acid. Amino acid is the basic structural unit of protein synthesis, the precursor of other amines required for metabolism, and is an indispensable material for life. At present, there are 20 to 30 kinds of amino acids known, some of which can be synthesized in human body, called nonessential amino acids, some of which cannot be synthesized in human body, and must be supplemented from outside, called essential amino acids. Mammalian cells need 12 kinds of essential amino acids: L-arginine, L-cystine, L-histidine, L-leucine, L-isoleucine, L-lysine, L-methionine, L-phenylalanine, L-threonine, L-tryptophan, L-tyrosine L-valine. These amino acids are all left-handed isomers, while some non-basic right-handed isomers of amino acids may have inhibitory effects on cultured cells. L-type amino acids are easier to absorb than D-type amino acids, but there is no difference in the absorption of D and L-methionine. The body competes for the delivery of amino acids. The delivery of one amino acid can be inhibited by the presence of another amino acid. For example, L-valine and L-methionine will inhibit the absorption of L-leucine. Excessive lysine in feed will inhibit the absorption of arginine. High concentration (100mM) of L-valine has no effect on the absorption of L-methionine because it can be transported through another route.

The main functions of feed additives: 1. Adding L-valine to the diet of lactating sows can improve the milk yield. Its mechanism of action is that valine can affect the synthesis of alanine and the release of muscle. Adding valine to sow diet can increase the level of alanine in plasma, so as to meet the demand of breast tissue for glucose raw material, thus improving the milk yield. Valine is of great significance to the production and development of the mammary gland. Valine is the limiting amino acid in the protein diet of lactating sows. The lack of valine can reduce the effect of lysine. Although adding lysine to the feed of lactating sows can improve the quality of the diet protein, it also causes the lack of valine, which affects the milk production of sows and the weight gain of piglets. When lysine level is high, valine will become the first limiting amino acid. 2. Improve the immune function of animals. Valine can promote the transformation of animal skeletal cells into mature T cells. Valine deficiency can reduce the level of complement C3 and transferrin, significantly inhibit the growth of thymus and peripheral lymph tissue, and inhibit the growth of acid and neutrophils. When weaned piglets lack valine, the ability to synthesize specific antibodies will decrease. Chickens lack valine, and their antibody response to newcastle disease virus is reduced. 3. It affects the endocrine level of animals. Studies have shown that the supplementation of valine in the diet of lactating sows and lactating rats can increase the concentration of prolactin and growth hormone in plasma.

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