Hesperitin(520-33-2)

Pharmacological effects: (1) Antioxidant effect: hesperidin can avoid the harm caused by peroxide reaction by removing peroxynitrite ion. (2) Anti-inflammatory effect: hesperidin can inhibit the mediating effect of inflammatory mediators, thus indirectly inhibiting the inflammatory reaction. Compared with hesperidin, hesperidin has stronger anti-inflammatory effect, and its anti-inflammatory activity is affected by the connection of hesperidin C7 with rutose. (3) Hypolipidemic effect: hesperidin can inhibit the production of cholesterol and the role of esterase, thus achieving the effect of reducing blood fat. (4) Cardiovascular protection: hesperidin has the effect of reducing blood lipids and vascular permeability, and can play a role in preventing thrombosis. Hesperidin can also protect endothelial cells from hypoxia by stimulating some mitochondrial enzymes, such as succinate dehydrogenase, and prevent thrombosis caused by coagulation caused by endothelial cell necrosis. In addition, hesperidin inhibits PLC γ 2 phosphorylation and its downstream signal transduction promote antiplatelet coagulation activity, can prevent thrombosis, and is beneficial to the cardiovascular system. (5) Anti-tumor effect: hesperidin has antioxidant effect, which can avoid canceration caused by gene changes caused by these factors. Promote the outflow of P-glycoprotein-mediated drugs from tumor cells. Flavonoids (hesperidin, etc.) can change the permeability of blood-brain barrier to vincristine, which is also related to its concentration. Low concentration of flavonoids can reduce the uptake of vincristine by brain capillary endothelial cells; On the contrary, high concentration can promote. Market prospect Foreign market situation: (1) Hesperidin is used in health drugs and health products, such as Amway's series of products are added with hesperidin. America's best-selling health care products have vitality of 50, and its main active ingredient is hesperidin. (2) As an additive of some cosmetics, such as CLARINS (Clarins), many night creams contain hesperidin. (3) In Japan, it is also used in food as an additive with the function of vitamin P. In China, hesperidin is mainly used as a drug raw material, and the main therapeutic effects of related drugs include stomach strengthening, expectorant, antitussive, expelling wind, diuretic, antipyretic and stomachache. The above information is edited by Chemicalbook Lili.