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Synephrine(94-07-5)

Plant extract: Synephrine is a biologically active substance, which is mainly extracted from rutaceae plants such as Fructus Aurantii, orange peel, and green peel. It is an effective component of Fructus Aurantii, which plays an important role in strengthening the heart, increasing cardiac blood output, contracting blood vessels, raising left ventricular pressure and arterial blood pressure due to high total peripheral vascular resistance, anti-shock and weight loss, However, because the structure of synephrine is similar to that of ephedrine, which has the potential side effects of stimulating the central nervous system and leading to cardiovascular diseases, its use has been restricted in the United States, Canada and other countries in recent years.

Chemical property: hydrochloride, colorless crystal (ethanol ether), melting point: 166 ℃ - 167 ℃[ α] 27D-52。 (C=7.6mg/ml, anhydrous methanol). Racemization is easy to occur in strong acid and strong base ion exchange resin chromatography. Crystallization, melting point: 184 ℃ - 185 ℃; Crystal melting point of hydrochloride: 151 ℃ - 152 ℃, easily soluble in water; Bitartrate, 188 ℃ - 189 ℃ (partial decomposition), soluble in water, insoluble in ether, almost insoluble in chloroform and ether.


Purpose: vasopressor. It is used for shock, heart failure, treatment of bronchial asthma, bottom blood pressure during surgery and anesthesia, collapse and shock, body and position hypotension, etc.


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