Tetrandrine(518-34-3)

Overview Tetrandrine (Tet), also known as tetrandrine, is a kind of dibenzyl isoquinoline alkaloid extracted from the root tuber of tetrandrine (Stephanite tetradra S. Moore), belonging to dibenzyl isoquinoline compounds, a new calcium antagonist, and an effective component of the main chemical book of tetrandrine; It has anti-inflammatory, analgesic, antihypertensive, anti-silicosis, hypoglycemic, anti-free radical damage, anti-liver fibrosis and other anti-tumor pharmacological effects; It is clinically used for simple silicosis and coal silicosis. It is also used for early mild hypertension, rheumatic pain, arthralgia, neuralgia, etc. It is also used for the treatment of liver cancer, lung cancer, colon cancer, bladder cancer and leukemia.

Application: 1. Tetrandrine, an immune system disease, can significantly inhibit the development of arthritis and has a stronger effect than aspirin. It can be used in the treatment of rheumatoid arthritis. 2. Tetrandrine, a cardiovascular disease, not only has calcium antagonistic effect, but also can inhibit the T-type and L-type calcium channels of ventricular myocytes, and interact with M receptor to block the calcium-activated potassium channels, becoming a treatment method for paroxysmal supraventricular tachycardia. 3. Tetrandrine in the digestive system plays a certain role in protecting hepatocytes and preventing liver fibrosis. 4. Tetrandrine, an ophthalmic disease, is used for the treatment of ocular inflammation, including uveal Chemicalbook membranitis, keratitis and retinopathy. 5. Other tetrandrine has obvious antagonistic effect on the acute nephrotoxic effect caused by streptomycin, can reduce the apoptosis and proliferation of renal tubular epithelial cells, protect renal function, protect renal injury caused by acute ischemia and reperfusion, can significantly reduce serum creatinine and urea nitrogen levels, improve glomerular filtration rate and renal plasma flow, and delay the development of glomerulosclerosis. Overview, physical and chemical properties, pharmacological action and application of tetrandrine

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