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Astragaloside A(83207-58-3)

Overview: Astragalus mongholicus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. Astragalus membranaceus is a perennial herb, which is resistant to cold, drought, heat and waterlogging. It grows mostly in dry sunny hillside grassland or sunny forest edge bushes. It should be cultivated in a cool and dry climate, preferably in a sandy soil with good drainage and deep soil layer. Astragalus mongolicus is distributed in parts of northeast and north China; Astragalus membranaceus is distributed in some provinces and regions in North China, Northwest China, Northeast China and Southwest China. Astragalus membranaceus is a commonly used Chinese medicine with warm nature and sweet taste. It has the functions of tonifying qi and consolidating the surface, diuresis and detoxification, discharging pus, and astringing sores and muscles. It is used for qi deficiency and fatigue, less food and loose stools, sinking of middle qi, chronic anal discharge, bloody stool and metrorrhagia, spontaneous sweating due to deficiency of the surface, edema due to qi deficiency, chronic nephritis, albuminuria, diabetes and other diseases. Modern pharmacological studies have shown that astragalus has the effects of enhancing the body's immune function, strengthening heart and blood pressure, lowering blood sugar, diuresis, anti-aging, anti-fatigue, etc. The main active ingredients in astragalus are astragalus polysaccharides, astragalus saponins and isoflavones. At present, astragaloside IV in astragalus saponins is mainly used as the standard to evaluate the quality of astragalus.

Pharmacological effects: 1. Astragaloside IV can inhibit oxidative stress, reduce the level of reactive oxygen species (ROS) in cells, strengthen the antioxidant defense system, increase anti-apoptosis and anti-inflammatory pathways, and regulate the differentiation and infiltration of T cells in the central nervous system. Therefore, astragaloside IV may be used in the treatment and prevention of MS. In short, astragaloside IV can play a certain role in many diseases by regulating the immune function of the body. 2. Astragaloside IV has protective effects on brain injury, lung injury, kidney injury and heart injury caused by ischemia and reperfusion. 3. In addition to its protective effect on myocardial injury caused by ischemia and hypoxia, astragaloside IV has certain effects on myocardial hypertrophy, myocarditis, myocardial fibrosis, etc. 4. Astragaloside IV has effects on pneumonia, airway inflammation, asthma and acute pancreatitis through its anti-inflammatory activity. 5. Astragaloside IV up-regulates IFN- γ The expression at mRNA level plays an anti-CVB3 role. 6. Astragaloside IV induces TNF in 3T3-L1 adipocytes by inhibiting the activities of hepatic glycogen phosphorylase (GP) and glucose-6-phosphatase (G6Pase)- α Secrete, improve insulin tolerance and play a hypoglycemic role. 7. Astragaloside A has certain inhibitory effect on lung cancer, liver cancer, breast cancer and gastric cancer in vitro.

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