Carnosicacid(3650-09-7)

Rosemary extract: Rattail oxalic acid is a diterpenoid compound separated from the leaves of the plant Rosemary Rosmarinus officinalis, a white or yellow-white powder, which is easily soluble in oil and ethanol, ethyl acetate, acetone, chloroform and other organic solvents, and insoluble in water. Rattail oxalic acid is suitable for antioxidation of oil-soluble components. Used in sauces, pet food and feed, it has the function of anti-oxidation and anti-aging; It has the effect of reducing weight and fat; Treatment of cardiovascular disease and anticancer effect. Rosemary (Rosemarinus), a herb of labiaceae, is native to southern European countries. It has been introduced and cultivated in Hunan, Guizhou, Hainan, Guangxi, Guangdong and other provinces and cities in China. It contains a variety of effective ingredients such as sage acid, rosemary phenol, rosemary acid, sage phenol, epirosemary phenol, isorosemary phenol, rosemary diphenol, etc. The most effective antioxidant substances are sage acid, rosemary phenol and sage phenol. The fat-soluble rosemary extract is light yellow to yellowish brown powder or brown paste, insoluble in water, soluble in ethanol and oil; The water-soluble rosemary extract is a brown powder with the unique smell of rosemary. Good heat resistance (stable at 200 ℃) and UV resistance, which can effectively prevent the oxidation of oil. Rosemary extract can be divided into oil soluble (antioxidant) and water soluble (antioxidant and preservative). The effective component of the former is mainly murine oxalic acid, and the latter is mainly rosemary phenol. Rosemary extract is naturally non-toxic, and its antioxidant effect is far higher than the existing natural antioxidants such as vitamin C, vitamin E, tea polyphenol, and is 2 to 4 times of the synthetic antioxidants BHA and BHT. Its structure is stable, and it is not easy to decompose, and it can withstand the high temperature of 190 ℃ to 240 ℃. It completely overcomes the fatal weakness of most natural antioxidants such as vitamin C, tea polyphenol, and so on, which decompose at high temperature. Therefore, compared with other similar products, It has the advantage of more efficient and broad spectrum. Researchers found that the antioxidant activity of rosemary extract at 300 mg/kg was equivalent to 200 mg/kg BHA, and greater than 100 mg/kg tocopherol. Generally, its antioxidant capacity increases with the increase of the amount added, but at high concentration, it can cause the oil to precipitate and discolor the water-bearing food. The antioxidant function of rosemary mainly lies in its ability to quench singlet oxygen, remove free radicals, chelate metal ions and synergism of organic acids.

Pharmacological action of murine tail oxalic acid: (1) The study of antibacterial action shows that murine tail oxalic acid has different degrees of inhibition on Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Saccharomyces Hansen, and can be used as a food preservative. (2) Antioxidant effect Sargassum oxalate has good free radical scavenging and antioxidant effects. Its DPPH, ABTS free radical scavenging ability and iron reduction antioxidant ability are stronger than VE, and slightly weaker than synthetic antioxidant TBHQ; Its reduction capacity is stronger than VE and TBHQ. Rattail oxalic acid is fat-soluble, which can effectively inhibit the formation of peroxide and the decomposition of polyene fatty acids in oil, thus extending the shelf life of oil. In addition, the study found that salvia acid can effectively eliminate oxygen free radicals in mouse liver cells, reduce the production of lipid peroxide, and stabilize the cell membrane; Oxalic acid in rat tail can also inhibit the oxidation reaction of low k density lipoprotein, which can effectively prevent the occurrence of atherosclerosis. (3) Other studies have found that murine tail oxalic acid has an inhibitory effect on the proliferation of HL-60 cells, and is expected to become a new drug for the treatment of blood malignant tumors, for the treatment of cardiovascular diseases and anti-cancer. Kaloustian et al. introduced that rosemary extracts such as carnosic acid have certain therapeutic effects on heart disease and respiratory diseases, have antibacterial effects, and can also inhibit HIV infection. Ninomiya et al. reported that rosemary extract such as murine tail oxalic acid can not only control people's weight by effectively regulating fat absorption, so as to achieve the goal of weight loss, but also can treat inflammation, sore throat, dyspepsia, prevent Alzheimer's disease, treat diabetes, and promote the production of nerve growth factor.

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