Puerarin(3681-99-0）

Introduction: Puerarin, also known as puerarin flavone, is a natural isoflavone glycoside, and is the key component of puerarin to exert its efficacy. Puerarin has the effects of reducing blood sugar, regulating blood lipid, protecting blood vessels, anti oxidative stress, anti infection, improving insulin sensitivity index, and has fewer adverse reactions. It is known as "phytoestrogen" and is clinically used to treat cardiovascular and cerebrovascular diseases, cancer, Parkinson's disease, Alzheimer's disease, diabetes, and diabetes complications.

Purposes The crude extract of pueraria and puerarin can regulate the proliferation inhibition, apoptosis-induced chemicalbook and cell cycle of SMMC-7721 hepatoma cells, both of which can inhibit their growth to varying degrees, and the crude extract of pueraria can promote the apoptosis of SMMC-7721 cells. Puerarin can promote human T lymphocytes γδ T proliferation, and can improve its killing activity, while γδ T cell proliferation may be related to the activation of P-ERKL/2 signal pathway by puerarin and the expression of anti-apoptotic protein Bcl-2, γδ The increase of cytotoxicity of T cells to hepatoma cell line SMMC-7721 may be related to γδ Granulase B, perforin and CD107a expression of T cells are related.

harmacological action: Pueraria lobata is the root of Pueraria thomsonii Benth. or Pueraria lobata (Wild.) Ohwi. It tastes sweet, spicy and cool. Return to the spleen, stomach and lung meridians. It has the effects of relieving muscle and fever, penetrating rash, promoting saliva and thirst, raising yang and stopping diarrhea, unblocking meridians and activating collaterals, and detoxifying alcohol. It is often used in external headache, fever, strong pain in the neck and back, measles, thirst, thirst, heat dysentery, diarrhea, dizziness, headache, stroke, hemiplegia, chest pain, and alcohol poisoning. Puerarin contains a variety of effective ingredients, mainly puerarin. Puerarin is also known as 8-beta-D-glucopyranose-4 ', 7-dihydroxyisoflavone in Chinese. Recent studies have shown that puerarin has a good effect on sudden deafness and cardiovascular and cerebrovascular diseases. Used to expand blood vessels and improve blood circulation; Reduce myocardial oxygen consumption and inhibit cancer cells; Increase coronary flow and adjust blood microcirculation; Treatment of sudden deafness at all ages; Reduce the risk of cardiovascular and cerebrovascular diseases. With the in-depth study of the pharmacological effects of Pueraria lobata, various kinds of food and drugs processed as raw materials have been widely praised by the people at home and abroad.

Pharmacological effect: puerarin can eliminate free radicals in the body to different degrees, reduce lipid peroxidation damage, and improve the activities of antioxidant enzymes in the body, such as SOD, glutathione peroxidase, and catalase. Puerarin can improve immunity, improve microcirculation, expand blood vessels, increase Chemicalbook and coronary flow, reduce blood pressure, slow heart rate and reduce myocardial oxygen consumption without obvious negative myodynamia. It also has the effects of antithrombotic, improving high-density lipoprotein, anti-vasospasm and reducing platelet aggregation. Puerarin can treat diabetes by reducing blood glucose concentration. Puerarin can up regulate insulin receptor substrate IRS-1 and insulin-like growth factor IGF-1 protein, and promote insulin receptor InsR and peroxisome proliferator activated receptor PPAR α To reduce blood sugar and treat diabetes. In addition, puerarin can also inhibit α- The activity of glucosidase can reduce the blood sugar concentration and achieve the purpose of treating diabetes. The study found that puerarin treatment of type 2 diabetes patients can improve the body's sensitivity to insulin, and puerarin drugs can weaken insulin resistance, thus treating diabetes. Puerarin can also inhibit TNF in plasma- α It can improve the sensitivity of the body to insulin level and reduce blood sugar content. In addition, the application of puerarin in diabetes retinopathy helps to reduce the blood flow resistance of the ophthalmic artery, speed up the blood flow, promote the expansion of the muscular artery, and reduce local thrombosis. It has a preventive effect on diabetes retinopathy, and puerarin also has a therapeutic effect on diabetes in pregnancy.

Chemical properties: white acicular crystal, soluble in water, methanol and ethanol when heated, insoluble in ethyl acetate, chloroform and benzene, and derived from pueraria lobata.

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